Abstract:

Objective: Timing for laryngeal biopsy is challenging for geriatric patients due to their comorbidities and anesthetic risks. The aim of this study is to find an indicator that would both allow surgeons to predict the need for laryngeal biopsy, and to diagnose the malignancy at an early stage. Material and Methods: This is a retrospective cohort study of 103 participants. Three groups were constituted according to the results of laryngeal biopsy (benign-Group 1, premalignant-Group 2, and malignant-Group 3). The neutrophil: lymphocyte ratio, the platelet: lymphocyte ratio, and the systemic immune- inflammation index (neutrophil count × platelet count) / lymphocyte count) values of the three groups were compared between groups. Results: The male: female ratio was 100:3, and the mean age was 70.87 (±6.38) years, with no significant differences among the three groups [Group 1: 70.40 (±5.94), Group 2: 70.44 (±5.09), Group 3: 71.15 (±6.91)] (p=0.88). There were no statistically significant differences among the three groups in neutrophil: lymphocyte ratio (p=0.84), platelet: lymphocyte ratio (p=0.36), or systemic immune-inflammation index values (p=0.67). Conclusion: Indices calculated from haematological parameters and showing systemic inflammation may not be reliable in the geriatric population due to immunosenescence. For this reason, indices calculated from haematological parameters should be studied distinctly in the geriatric population without including other age groups. Other methods are needed to help predict the timing of laryngeal biopsy in geriatric patients.

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