Abstract:

In this study, it was aimed to comparatively investigate the effect of  diet type and feeding frequency on occurence of experimental ulcerative colitis (UC), in Wistar albino rats. For this purpose, 7 rats were randomly selected and 6 groups were formed as Control (n=7), Colitis (n=7), Colitis-High Carbohydrate Diet (C-HCD) (n=7), Colitis - High Carbohydrate Diet with Intermittent Feeding (C-HCIFD) (n=7), Colitis -High Fat Diet (C-HFD) (n=7), Colitis-High Fat Diet with Intermittent Feeding (C-HFIFD) (n=7). In intermittent feeding groups the feeding  was interrupted twice in a week for 24 hours . After 7 weeks of feeding, experimental colitis model was induced in colitis and treatment groups rats by intrarectal administration of acetic acid (pH 2.4, 4 %). After the 72 hours rats were sacrificed and colon samples were taken into 10% formalin solution. Histopathological studies have shown that acetic acid caused severe colitis damage, whereas the damage remained at minimal levels in groups with intermittent feeding. As a result, it was concluded that intermittent feeding administration in the colitis model had positive effects.

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