Özet:

Aim: Autism Spectrum Disorder (ASD) is a neurodevelopmental disease with an average diagnosis age over three years. Metabolomic studies pointing out candidate amino acids are of major importance to guide trained clinicians for an early and faster diagnosis. We aimed to evaluate 37 plasma amino acids in children with ASD compared to age and sex matched controls in this study. Method: Twenty three children diagnosed with ASD in Research and Training Hospital (19 boys and 4 girls) and, age and gender matched 24 children without ASD were enrolled in this study. A total of 37 amino acid levels were measured with LC-MS/MS device. Results: While anserine, asparagine, citrulline, glutamic acid, hydroxyproline, N-methyl-histidine, ornithine, valine were significantly lower, sarcosine was significantly higher in ASD group compared with control group. Conclusions: Studying the combination of plasma and urine amino acids related to urea cycle disorders can be recommended for new investigations. The significant decrease in hydroxyproline can create the potential to explain muscle weakness in ASD. Although it is difficult to say whether the difference in the levels of conflicting amino acids in the literature is due to methodological or biological differences, further studies will make the subject clearer.

Anahtar Kelimeler: