Abstract:

Epidemiological studies show that maternal nutrients taken in the sensitive development stages play an important role in increasing the likelihood to non-communicable chronic diseases such as cancer, obesity, diabetes, hypertension that may develop in the advanced period of life in pets. The question of how the maternal nutrition status affects the risk of chronic diseases of the next generation can be explained by epigenetic mechanisms. Epigenetic mechanisms reveal the relationship between early-term nutrition variations and long-term physiological effects by modifications of genetic expressions such as deoxyribonucleic acid (DNA) methylation or histon acetylation. Epigenetic dynamics, such as carbohydrates, fats and proteins, are known to be insufficient or sensitive to maternal nutrition. Experimental animal models and retrospective cohort studies show that maternal diet has contributed to the development of metabolic disorders by changing the epigenetic coding of the puppy's macro-nutritional element. The purpose of this collection is to study the impact of the contents of maternal macro nutrients taken in the critical stages of development on epigenetic mechanisms based on current literature.

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