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DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine
2021
Journal:  
Hacettepe Journal of Biology and Chemistry
Author:  
DOI:  
10.15671/hjbc.836685
Abstract:

The binding interactions of cis-[Pd(sac)2(PPh2Et)2] with DNA and HSA were comprehensively studied by a number of experimental methods and molecular docking studies. The Pd(II) complex bound to AT-rich sites in the major groove of DNA, and interacted with the hydrophobic cavity of the subdomain IIA of HSA. These experimental findings were supported by molecular docking studies. The Pd(II) complex had shown strong cytotoxic activity against different cancer cell lines and it also had selectivity especially for MCF-7 breast cancer cells higher than cisplatin.

Keywords:

2021
Journal:  
Hacettepe Journal of Biology and Chemistry
Author:  
DOI:  
10.15671/hjbc.836685
0
2021
Journal:  
Hacettepe Journal of Biology and Chemistry
Author:  
DOI:  
10.15671/hjbc.836685
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Hacettepe Journal of Biology and Chemistry

Field :   Fen Bilimleri ve Matematik

Journal Type :   Uluslararası

Metrics
Article : 779
Cite : 657
2023 Impact : 0.025
Details
Hacettepe Journal of Biology and Chemistry