Özet:

Objectives: Neoadjuvant chemoradiotherapy (CRT) is the standard treatment for locally advanced rectal cancer. We aim to examine clinical outcomes in locally advanced rectal cancer patients treated with neoadjuvant CRT retrospectively. Material and Method: The medical records of 35 patients who were diagnosed with locally advanced stage rectal cancer were analyzed retrospectively between the period of January 2009 and July 2012. Analyzed the data of patients were age, sex, histopathological fi ndings, location of tumors, clinical and pathologic tumor, node, metastasis (TNM) with postoperative histopathologic tumor regressions grades (TRG). Also, locoregional recurrence (LRR), distant metastases, and overall survival (OS) of the patients were determined.. Results: The mean age of patients were 56 (24-76), the median follow-up time was 21 months (6-40 months) and 17 patients (48%) were women, remaining 18 (52%) were male. During the follow-up period local recurrence was diagnosed in 3 (8,5%) patients. There was a signifi cant correlation between the tumor regression grade (TRG) with baseline T and N stage of the patients (P=0.10 and 0.047, respectively). There was no signifi cant correlation between the radiotherapy dosage and TRG as well as the other parameters. There were no signifi cant differences between the regimens of concomitant chemotherapy for the clinical outcomes. When examined the patients with local recurrence there was a signifi cant correlation between recurrence status, tumor differentiation (P=0.009) and tumor histology (P=0.017). No side effects were seen in 10 patients (28.5%). Grade 1 or grade 2 acute side effects of radiation therapy were observed in 25 patients (72%). Diarrhea was observed in 18 (72.00%) patients and dermatologic toxicities were in 17 (68.00%) in these patients. Conclusion: Neoadjuvant chemoradiotherapy is an important treatment method in patients with locally advanced rectal cancers. It laso contributes signifi cantly to local control and downstages for both T and N status. Local recurrence rates were also lower in these patients. 

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