Abstract:

Objective: To determine the relationship between the molecular subtypes and the clinicalopathological features (age at the diagnosis, histological type, histological grade, pT and pN stages) in breast cancer. Materials and Methods: The study population included 194 women with breast carcinoma, who were diagnosed between 2010 and 2015. The slides of the cases in the archive of the Süleyman Demirel University Faculty of Medicine Department of Pathology were reevaluated. Immunohistochemical ER, PgR, HER2 and Ki67 stained slides were used to perform the molecular subtyping. Results: Among the cases molecular subtypes were Luminal A [ER and/or PgR(+)/HER2(-)/Ki67 ≤ 14%] in 47.4% of cases,  Luminal B [ER and/or PgR(+)/HER2(+) or (-) /Ki67 > 14%] in 25.8% of cases, HER2 overexpressing [ER(-)/PgR(-)/HER2(+)] in 13.4% of cases, and triple negative [ER(-)/PgR(-)/HER2(-)] in 13.4% of the cases, respectively. Tumor grade and axillary lymph node metastasis in Luminal B, HER2 overexpressing and triple negative tumors were significantly higher than they were in Luminal A tumors. Lymphovascular invasion rate was significantly higher in HER2 overexpressing and triple negative tumors compared to Luminal type tumors. Conclusions: It was concluded that the molecular subtyping of the breast carcinoma, which is a heterogeneous tumor group, can give important information for the management of the cases along with the stage and other well-known clinicopathological features.

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