Özet:

Stachys lavandulifolia Vahl. is a flowering plant family belonging to the Lamiaceae family, which has a great place in ethnobotany. In this study, the phytochemical composition, inhibition of acetylcholinesterase (AChE) and paraoxonase (hPON 1) for antiatherosclerotic activity, and antioxidant capacity of the plant were investigated. Phytochemical content was determined by LC-MS/MS system, enzyme inhibition, and antioxidant capacity studies were determined by spectrophotometer. The antioxidant capacity of S. lavandulifolia extracts (methanol, hexane, and water) was determined by applying ABTS, DPPH, FRAP, and CUPRAC methods. The methanol extract of S. lavandulifolia exhibited significant inhibition of AChE (IC50 value for methanol extract 0.105±0.17 mg/mL (R2:0.978)). In contrast, methanol and water extracts of S. lavandulifolia showed no inhibitory effect on hPON 1. The highest activity for ABTS was 23.42% in methanol extract and 50.07% for DPPH activity in methanol extract. In the metal-reducing power test, the absorbance was 0.233±0.47 for FRAP water extract and 0.587±1.52 for CUPRAC methanol extract. According to LC-MS/MS analysis, luteolin, fumaric acid, caffeic acid, syringic acid, hydroxybenzoic acid, quercetin, salicylic acid, gallic acid, catechin hydrate, and acetohydroxamic acid were determined in the methanol extract of the plant. In conclusion, S. lavandulifolia, which has antioxidant, anti-atherogenic, and anti-neurodegenerative properties, has the potential to be used as a natural medicine instead of synthetic drugs used in Alzheimer's patients.

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