Abstract:

Compounds 2 were synthesised via the reaction of 4-amino-5-thiophen-2-yl-methyl-2,4-dihydro-[1,2,4]-triazol-3-one (1) with aldehydes. Compounds 3 and 4 were obtained from compounds 2 with bromo acetophenone and ethyl bromoacetate, respectively. The synthesis of compounds 2, 3, and 4 and crystal structure of compound 2a are being reported. The molecular structures were identified by IR, 1H-NMR, 13C-NMR, MS, and elemental analyses. Compound 2a crystallises in the monoclinic P 21/n space group, with a = 6.565(5) Å, b = 18.278(5) Å, c = 13.8166(18) Å, b = 96.227(5)°, V = 1553.6(14) Å3, Z = 4. The newly compounds synthesised were screened for their antibacterial and antifungal properties. Among the compounds, 4d showed antimicrobial activity against Candida albicans ATCC 60193 and Candida tropicalis ATCC 13803.

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