Özet:

Introductıon and objektive : Intrahepatic cholestasis (ICP) of pregnancy is a common disorder of pregnancy manifested by pruritus and elevated bile acids.Some negative obstetric outcomes of ICP; Spontaneous preterm birth, meconium amniotic fluid, fetal asphyxia and stillbirth have been reported in the literature. Due to the lack of evidence for diagnosis, treatment, and concomitant adverse outcomes, management has two main goals: reducing troubling symptoms and perinatal morbidity and mortality. Methods: Medical records of patients diagnosed and followed up with intrahepatic pregnancy cholestasis between January 2017 and June 2021 were reviewed retrospectively. Results: The mean week of delivery of the patients was 38.1±1.4, and no fetal or neonatal death occurred during their follow-up. Conclusion: With respect to the increased risk of adverse neonatal outcomes and stillbirth in patients with ICP, timing of birth in maternal ICP patients should be carefully evaluated. In conclusion, there is some evidence to suggest that birth at 37th weeks, especially in patients with severe bile acid level elevations, may improve outcomes. However as a result of this study in which the average gestational age at birth was 38 weeks and no fetal mortality occurred, we suggest that with close monitoring and early administration of treatment birth at 38 weeks could potentially improve outcomes in patients with low bile acid levels. Furthermore, optimal timing for birth in patients with ICP is as of yet unknown, due to the absence of randomized studies evaluating elective early induction of labor.

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