Özet:

Introduction and Target: Today, the increasing number of microorganisms resistant to antimicrobials causes serious problems in the treatment of bacterial infections. One of the main causes of resistance to antimicrobial substances is biofilms. Biophilus is a protective structure for microorganisms and the microorganisms in this structure can be up to 1000 times more resistant than planktonic forms against antimicrobial agents and desinfectants. This study aims to evaluate the biofilm formation activities of acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans microorganisms, which are often isolated from hospital infections. Method and Requirements: In this study, the biofilm production capacity of 25 A. baumannii, P. aeruginosa, S. aureus and C. albicans microorganisms, which are produced in cultures from various clinical samples sent from patients in the Republic University Medical Faculty's Application and Research Hospital services and in the intensive care units, was made using the microtitre plate method. Biophilic formations are based on negative control values; the biophilic formations are not estimated as = 0, weak biophilic formations = I, medium biophilic formations = II and strong biophilic formations = III. Results: After the study, 89% of the total isolates found biophilic formation at weak, medium and strong levels. A. baumannii, P. aeruginosa, S. aureus and C. The biophilming rates of albicans were found at 100, 88, 92 and 76 per cent, respectively. P. aeruginosa, A. baumannii, S. aureus and C. albicans microorganisms from the hospital have been found to form biophiles in significant proportions. In research on resistance development in microorganisms, it may be important to take into account this situation. We believe that the data obtained in our study will provide data to the literature for further studies on this subject.

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