Özet:

Objectives: The hepatitis B vaccine have been included in the routine vaccination program in our country since 1998 as part of the fight against hepatitis B virus (HBV). This study aimed to determine the HBV serology and to determine the effectiveness of the hepatitis B vaccination program in individuals born after the start of the hepatitis B vaccination program. Materials and Methods: Data from 302 patients born after the hepatitis B routine vaccination program and 172 persons born before the vaccination program were evaluated. Those with hepatitis B surface antibody (anti-HBs) <10 mIU/mL were defined as non-immune, those with anti-HBs ≥10 mIU/mL were defined as immune, and those with isolated anti-HBs positivity were defined as the vaccinated group. Results: Of the patients included in the study, 49.4% were female and 50.6% were male, with a mean age of 29.7±15.6 years. Anti- HBs, hepatitis B surface antigen (HBsAg), and anti-hepatitis B core antigen (anti-HBc) total positivity in patients were 41.4%, 3.2%, and 12.2%, respectively. 53% of the patients were unvaccinated, 36.5% were vaccinated, 4.4% were naturally immune, 3.2% were chronic hepatitis B, and 3% were isolated anti-HBc total positivity. A statistically significant difference was found in terms of HBsAg seropositivity anti-HBs seropositivity and naturally immune in individuals born before and after the routine hepatitis B vaccination program (p<0.05). Conclusion: With the data obtained at the end of our study, it was determined that there was a significant decrease in HBsAg seropositivity and innate immunity numbers following the implementation of the routine vaccination program. This highlights the importance of the vaccination program and the usefulness of vaccination in preventing HBV infections.

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