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INTRODUCTION: The comparison of laboratory parameters of non-vaccinated and inactivated coronavirus-vaccinated patients who came down with COVID-19. METHODS: The study was designed as a retrospective cross-sectional study between March 2020 and April 2021. 154 patients who had no vaccination(n=77) and one-dose (n=28) or two-dose (n=49) inactivated coronavirus vaccination, demographical data's, hemogram, C-reactive protein (CRP), ferritin and D-dimer levels were evaluated. RESULTS: In total, 154 patients were included in the study (84 female, 54.5%). The mean age was 65.1�14.5 years. The ferritin level was 449.93�443.48 ml/ng in one-dose vaccinated patients, 297.68�340.32 ml/ng in two-dose vaccinated patients and 568.70�539.41 ml/ng in unvaccinated patients; this difference was statistically significant (p=0.008). The D-dimer level was 0.86�0.89 �g/L in one-dose vaccinated patients, 0.67�0.79 �g/L in two-dose vaccinated patients and 1.62�1.93 �g/L in unvaccinated patients; again, a statistically significant difference existed (p=0.002). The rates of hospitalization in the ward and intensive care unit (ICU) and D-dimer levels were lower in two-dose vaccinated patients than in unvaccinated patients (p=0.015). No significant difference was detected concerning hemogram and CRP level of non-vaccinated, one-dose vaccinated and two-dose vaccinated patients. DISCUSSION AND CONCLUSION: Even if vaccinated, individuals can get COVID-19, but disease progression is milder, and ferritin and D-dimer levels related to disease severity are higher in unvaccinated patients.

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