Özet:

Aim: We aimed to investigate the presence of hepatitis B virus (HBV) reactivation, chronic and occult HBV in patients who are followed in the Physical Medicine and Rehabilitation Clinic of Zonguldak Bülent Ecevit University Health Practice Research Hospital and using biological disease modifying drugs (bDMARDs). Material and Methods: The data files of the patients with ongoing biological disease-modifying antirheumatic drug (bDMARD) therapy that was followed by the Physical Medicine and Rehabilitation Clinic were analyzed retrospectively. Patient data such as age, gender, diagnosis, medication and its duration, Hepatitis B antigens and antibodies (HBsAg, anti-HBs and anti-HBc IgG), and antiviral HBV treatments were recorded. Results: The study included 138 patients comprising 64 (46.4%) females and 74 (53.6%) males. The mean age was 47.7±11.9 years. HBsAg, anti-HBc IgG, and anti-HBs positivity were detected in 4 (2.9%), 47 (34.8%), and 63 (45.6%) patients in our outpatient clinic, respectively. Thirty-two (23.2%) of the patients were receiving antiviral treatment. Close HBV DNA monitoring was performed for 3 months in 15 patients with (+) anti-HBc IgG, these patients were not followed by antiviral treatment. Totally 16 patients were vaccinated against Hepatitis B. Conclusion: As a consequence of the study, no HBV reactivation was encountered in the clinical follow-up of 47 patients with an ongoing medication of meanly 5 years for chronic and occult HBV. We concluded that the development of a feared complication such as HBV reactivation can be prevented in patients using bDMARDs with strict follow-up and appropriate protocol

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