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Amaç: Hyaluronik asidin ve mineralize allogreftin sıçan tibiasında oluşturulmuş defektlerde yeni kemik formasyonu ve kemik iyileşme skoru üzerine etkisinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: 52 adet Spraque-Dawley cinsi sıçan 4 gruba ayrılmıştır: mineralize kemik greft grubu, hyaluronik asit grubu, hyaluronik asit ile kombine olarak uygulanan mineralize kemik greft grubu ve boş defektlere sahip kontrol grubu. Hayvanlar postoperatif 7. ve 21. günlerde sakrifiye edilmiştir. İnflamasyon, nekroz, fibrosis, yeni kemik oluşumu ve kemik iyileşme skoru histopatolojik olarak değerlendirilmiştir. Bulgular: Yeni kemik oluşumu kontrol grubunda deney grubuna göre anlamlı oranda daha yüksek bulunmuştur. Ayrıca yalnızca hyaluronik asit ve yalnızca greft gruplarına kıyasla, kontrol grubunda iyileşme skoru daha yüksek bulunmuştur. Greft ve hyaluronik asit grupları kıyaslandığında, 7. gündeki nekroz kontrol grubunda anlamlı oranda düşükken, 21. günde gruplar arasında anlamlı bir farklılık bulunmamıştır. 7. ve 21. günlerdeki inflamasyon ve fibrozis değişkenlerinin oranları gruplar arasında anlamlı bir değişiklik yaratmamıştır. Sonuç: Hyaluronik asit tek başına veya mineralize kemik allogrefti ile birlikte uygulandığında, sıçan tibiasında oluşturulmuş kritik boyutta olmayan defektlerde kemik rejenerasyonununda yeterli katkıyı sağlamamıştır.
Purpose: This study is aimed at assessing the levels of anxiety-depression and bodybuilding of patients planned with the diagnosis of a chronic painful disease of osteoartritis (OA). Tools and Methods: The diagnosis of OA and the planned patient and the patient group of people that can match in terms of demographic data were included in our work as a healthy control group. All participants were applied to the sociodemographic data form, the Hospital Anxiety Depression Scale (HADÖ), the Penn Situational Anxiety Scale (PDAÖ), the Body Emotions Increasing Scale (BDBÖ). The results: 64 people were included in our work. The patient's average age is 64.77±8.14, while the healthy control group is 65.22±9.15. When the relationship between the quantum variables was studied, it was found that OA patients for ADHD received higher results from the control group in both anxiety, low-dimensional depression and total scale. For PDAÖ and BDBÖ, the patient group received a lot higher score according to healthy controls. The result: In the results we obtained, it was found that patients with chronic painful disease of OA had excessive pre-chirurgical anxiety-depression and bodybuilding scores. Based on these findings, OA patients are recommended to be psychosocially well supported in both the path of the disease and before the surgery, to be able to help more patients, to facilitate their adaptation to the surgery.
Purpose: This study aimed to evaluate the effects of hyaluronic acid (HyA) and gamma-radiated mineralized allografts (Gr-MAs) on the healing of bone defects in rat tibiae. Materials and Methods: Fifty-two male Sprague Dawley rats were randomly allocated to four groups: Gr-MA, HyA, Gr-MA combined with HyA (Gr-MA + HyA), and controls with empty defects. The animals were sacrificed on the 7th and 21st postoperative days. The inflammation, necrosis, fibrosis, new bone formation, and bone healing scores were evaluated on the basis of the histopathological findings. Results: The amount of new bone formation was found to be significantly greater in the control group than in the experimental groups. In addition, the healing scores were statistically higher in the control and the Gr-MA + HyA groups. Comparisons of the control, graft, and HyA groups indicated that the control group exhibited significantly less necrosis on the 7th day; however, on the 21st day, there were no statistically significant differences among the groups. There were no statistically significant differences among the groups in terms of the inflammation and fibrosis levels on the 7th or 21st days. Conclusion: Within the limitations of this study, the application of HyA alone and the addition of HyA to Gr-MA did not improve bone regeneration in rat tibial defects.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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