Abstract:

Abstract Objective: Cerebral Vein Sinus Thrombosis (CVST) is a clinical condition that manifests itself with a wide variety of nonspecific symptoms and arises due to different etiologies. It is a rare disease that may not be easily diagnosed. Investigation of gynecological and obstetric causes in patients with Cerebral Vein Sinus Thrombosis (CVST). Material and Methods: Patients who admitted to Fırat University Medical Faculty Hospital between November 2010 and November 2020 with neurological complaints and were diagnosed with CVST in the evaluation performed and women who developed CVST due to obstetric/gynecological reasons were retrospectively analysed. The complaints, neuroradiological findings and treatments applied were determined from the records of the women. Descriptive statistics were used in the evaluation of the data. Results: At the time of the study period, 166 cases were diagnosed with CVST. One hundred and five of the cases were female (63.2%) and 61 were male (36.8%). It was found that CVST developed secondary to obstetric and gynecological causes in 15 cases (9%). The most common symptom was headache (80%) and the most common finding was papillary edema (20%), hemiparesis (13.3%) and hemiplegia (6.7%). Six cases (40%) included in the study were in the puerperal period. Of these, two cases (13.3%) gave birth by vaginally and four cases (26.7%) by caesarean. Five of the cases (33.3%) were pregnant. All of the pregnant women were in the third trimester of pregnancy. It was found that mastoiditis developed in one case (6.7%) and she delivered vaginally 4 months ago. One case (6.7%) had sinusitis and a family history of postpartum deep thrombosis was detected. Two cases (13.3%) were using combined oral contraceptives (OCS), and in one of them, MTHFR homozygous mutation and high homocysteine levels were detected. When all cases were evaluated, 7 cases (4.2%) had a diagnosis of hereditary thrombophilia. Conclusion: Obstetric and gynecological reasons, especially pregnancy, puerperal period and use of OCS, take up almost 10% of CVST cases and should be taken into consideration during the evaluation.

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