Abstract:

Purpose: Low thyroid hormone levels have been to increase the risk of bleeding, while high levels have been to increase the risk of venous thromboembolism. However, the relationship between congenital hypothyroidism (KH) and intraventricular hemorrhage (IVH) is not known especially in premature babies. Our study aims to investigate the relationship between severe intrakranial bleeding and KH in premature babies with very low birth weight.  Instruments and Methods: Between January 2013 and December 2016, the data of CDA patients based on the newborn intensive care unit was recorded retrospectively. Patient pregnancy weeks (GH), birth weight (DA), gender, 1 and 5. Minute Apgar score, antenatal steroid administration, maternal thyroid disease, cranial ultrasonography findings, thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels were recorded. Patients with and without congenital hypothyroidism were compared in terms of demographic characteristics and severe IVH. The data of VLBW infants admitted to the neonatal intensive care unit were recorded retrospectively between January 2013 and December 2016. Gestational week (GH), birth weight (BW), gender, 1st and 5th Apgar score, antenatal steroid administration, maternal thyroid disease, cranial ultrasonography examination reports and thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels obtained from the records. Demographic characteristics and intraventricular hemorrhage were compared between groups with and not with KH.  Results: In our study, 581 CHDDs were found in 26 babies (4.5%) with KH. The pregnancy week (27.3 ± 1.04 weeks) and DA (978 ± 197 g), infants with KH, were lower than non-KH (GA 28.1 ± 1.2 weeks, DA 1073 ± 226 g) (respectively, p <0.00, p = 0.037). There was no significant difference in terms of severe HIV (p = 0.95) between KH (7.7) and KH (6.5) groups. The sT4 level was significantly low in the group of severe HIV (evre≥3) (p = 0.018). The results of the thyroid-stimulating hormone were similar among groups with serious HIV and non-HIV (p = 0.215).  The conclusion: In our study, we have found that KH did not increase the serious risk of HIV in the CDA prematures. However, low levels of sT4 in the severe IVH group have been believed to be due to critical disease and hypothalamic insufficiency to brain damage.

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