Özet:

In 2002 and 2012, the previous coronavirus epidemics, the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) were revealed. Then in December 2019, another highly pathogenic coronavirus called SARS-CoV-2 appeared in the city of Wuhan, Hubei, China, and rapidly spread throughout the world. On March 11, 2020 the disease was declared a worldwide epidemic disease. This virus, called COVID-19 by the World Health Organization (WHO), is transmitted through inhalation or infected drops and the period of infection ranges from 2 to 14 days. The virus, illness, dry cough, fever, nausea, vomiting, smell loss, headache, and most important causes respiratory failure. Many people are asymptomatic. The disease appears lightly in most people; in some (usually in the elderly and with chronic illness) it can advance to pneumonia, acute respiratory failure syndrome (ARDS) and multiple organ function disorder. The death rate is estimated to be between 2% and 3%. SARS-CoV-2 infects the residential cells through the receptors of angiotensin conversion enzyme 2 (ACE2). Increased evidence shows that coronavirus is not always limited to the respiratory pathways, and it can invade many organs where ACE2 receptors are located. Since December 2019, the number of cases in the world has exceeded 14 million and the number of deaths has exceeded 619 thousand. In Turkey, the number of COVID-19 positive cases has approaching 225 thousand, and unfortunately the number of people separated from us has exceeded 5500. This collection reports the histopathological findings of biopsy samples taken from different organs of people who have died due to COVID-19.

Anahtar Kelimeler:

Özet:

In 2002 and 2012, severe acute respiratory syndrome coronavirus (SARS‐CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), which were previous outbreaks of corovavirus, appeared. Then, in December 2019, another highly pathogenic coronavirus named SARS-CoV-2 appeared in Wuhan City, Hubei province of China, and it spread rapidly all over the world. On March 11, 2020, the disease was declared as a pandemic, a global epidemic. Called COVID-19 by the World Health Organization (WHO), this virus is transmitted through inhalation or infected droplets and the incubation period ranges from 2 to 14 days. This virus causes dry cough, fever, nausea, vomiting, loss of smell, headache and most importantly respiratory distress. Many people are asymptomatic. The disease is mild in most people; in some (usually the elderly and those with chronic disease) it can progress to pneumonia, acute respiratory distress syndrome (ARDS) and multi-organ dysfunction. The case death rate is estimated to be between 2% and 3%. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells through ACE2 receptors. Increasing evidence suggests that coronaviruses are not always limited to the airways, but can invade many organs with angiotensin converting enzyme 2 (ACE2) receptors. The number of cases has exceeded 14 million and the number of deaths exceeded 619 thousand in the 8-month period since December 2019, when the first case occurred worldwide. In Turkey, the number of COVID-19 positive cases has approached 225 thousand and unfortunately the number of people who died has exceeded 5500. In this review, histopathological findings of biopsy samples taken from different organs of people who died due to COVID-19 are reported.