Abstract:

This study aimed to investigate of the antimicrobial activities of some amino acid-Schiff bases complexes as theoretical aspects. Co(II), Cu(II) and Ni(II) complexes of N,N'-(1,4-phenylenedimetiliden)bis DL-Alanine and N,N'-(1,4-phenylendimetiliden)bis DL-Glisine were been prepared and characterized. The antibacterial and antifungal activities were measured by Disc diffusion and MIC method against gram-positive bacteria i.e. Psydomamonas aeruginosa ATCC 29212, Bacillus subtilis RSKK 244, Bacillus megaterium(clinical isolate), gram-negative bacteria Micrococcus Luteus NRRLB and as fungus Candida albicans. The antibiogram tests of amino acid-Schiff bases complexes showed better results than some known antibiotics. Especially Cu(II) complexes were more potent bacteridal than all of the substances synthesized. Furthermore a mechanism of reaction was offered in the explanation of these observation. Some of the compounds exhibited activity comparable to Ketoconazole, Ampicillin, Tetracycline, Penicillin, Gentamisin and Chloroamphenicol. 

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