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Naproxen Derivative Interaction Properties with ct-DNA
2019
Journal:  
Hacettepe Journal of Biology and Chemistry
Author:  
DOI:  
10.15671/hjbc.517481
Abstract:

Interaction mode of a naproxen derivative (NH) with ct-DNA was explored by absorption and fluorescence spectroscopy. The experimental results revealed the static quenching as a result of groove binding between the naproxen derivative and ct-DNA. Computational studies were carried out to deeper understanding of the interactions. Molecular docking calculations shown that the interaction between NH and ct-DNA is resulted by groove binding. In addition to spectral data, docking studies revealed that NH-A_DNA and NH-B_DNA complexes had different interaction and conformational trends to each DNA isomer.

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2019
Journal:  
Hacettepe Journal of Biology and Chemistry
Author:  
DOI:  
10.15671/hjbc.517481
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Hacettepe Journal of Biology and Chemistry

Field :   Fen Bilimleri ve Matematik

Journal Type :   Uluslararası

Metrics
Article : 779
Cite : 657
Details
Hacettepe Journal of Biology and Chemistry