Özet:

In this study, the effects of copper oxide nanoparticles at different concentrations (10, 100 and 1000 µg/mL) on catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-s-transferase (GST) and acetylcholinesterase (AChE) activities were investigated in the midgut and fat body of Galleria mellonella larvae. It was determined that GPx activities increased in the group exposed to 100 µg/mL copper oxide nanoparticles, whereas a decrease in CAT, SOD and AChE activities was observed in midgut and fat body of G. mellonella larvae exposed to all copper oxide nanoparticles applied groups. Moreover, GST activity decreased in fat body in all applied groups, while an increased was observed in midgut of G. mellonella larvae when exposed to copper oxide nanoparticles. Overall, these findings indicate that oxidative stress occurs due to the accumulation of reactive oxygen species as a result of the toxicity of the copper oxide nanoparticle of G. mellonella larvae.

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