ÖZET Giriş; Posterior reversible ensefalopati sendromu (PRES) , nörolojik ve radyolojik bulguların eşlik ettiği geri döndürülebilir bir sendromdur. İlk olarak 1996 yılında Hınchey J ve ark. tarafından tanımlanan bu sendrom genellikle hipertansiyon, baş ağrısı, konfüzyon, konvülziyon,kusma ve görme bozukluğunun eşlik ettiği geri döndürülebilir bir hastalık olarak literatüre geçmiştir. Patofizyolojisinde iki hipotez öne sürülmüştür, birincisi aniden yükselen tansiyona bağlı olarak serebral hiperperfüzyon ve buna bağlı vazojenik ödem, ikincisi ise endojen ve eksojen toksinlerin neden olduğu endotel disfonksiyonudur. Klinik olarak çeşitli nörolojik semptomlarla karekterize olup, akut veya subakut gelişebilir. Birkaç saat sürebildiği gibi günler ve haftalarca da sürebilir. Gereç ve Yöntem; Bu çalışma 2012-2017 yılları arasında Adıyaman Üniversitesi Tıp Fakültesi Acil Servise başvuran hastalar arasından retrospektif olarak yapıldı. Baş ağrısı, ensefalopati, nöbet, görme bozukluğu veya fokal nörolojik defekti içeren akut başlangıçlı nörolojik semptomlar ve beyin görüntülemesinde fokal vazojenik ödem tespit edilen beş PRES olgusu çalışmaya alındı. Olgular yaş, cinsiyet, acil servise başvuru şikayeti,kronik hastalık, gebelik durumu, BBT,MR ve elektroensefalografik (EEG) bulgularına göre sınıflandırıldı. Sonuç olarak; acil servise baş ağrısı, görme kaybı, bilinç kaybı ve özellikle konvülziyonla başvuran kadın ve gebelerde PRES akla gelmelidir. Anahtar Kelimeler: PRES, acil servis, konvülziyon ABSTRACT Background: Posterior reversible encephalopathy syndrome (PRES) is a reversible syndrome accompanied by neurological and radiological findings by Hynchy J et al. in 1996 . This syndrome is often referred with hypertension, headache, confusion, convulsions, vomiting, and loss of vision.Two hypotheses have been proposed for pathophysiology. The first being cerebral hyperperfusion due to suddenly elevated blood pressure and the associated vasogenic edema and the second endothelial dysfunction caused by endogenous and exogenous toxins. It is clinically characterized by various neurological findings which may develop acutely or subacutely. It can last for several hours or days and weeks. Material and method: This study was retrospectively performed between Adiyaman University Faculty of Medicine Emergency Service between 2012-2017. Acute onset neurological symptoms including headache, encephalopathy, seizure, visual impairment or focal neurologic deficit, and five PRES cases with focal vasogenic edema on brain imaging were included in the study. The cases were classified according to age, gender, complaint of emergency service, chronic disease, pregnancy status, BBT, MR and electroencephalographic (EEG) findings. Conclusion: As a result; emergency headache, visual loss, loss of consciousness, and PRES in women and pregnant women, especially those who are referred for convulsions. Keywords: PRES,emergency, convulsions
Posterior reversible encephalopathy syndrome (PRES) is a reversible syndrome accompanied by neurological and radiological findings. First in 1996 Hınchey J and ark. This syndrome, which is defined by, has often passed into literature as a reversible disease accompanied by hypertension, headache, confusion, convulsion, swelling and vision disorders. There are two hypotheses in patophysiology, the first is cerebral hyperperfusion and related vasogenic swelling due to sudden rise in pressure, and the second is endothelial dysfunction caused by endogenous and exogenous toxins. It is clinically caregated with a variety of neurological symptoms, and can develop acute or subacute. It can take days and weeks as it can take a few hours. Tools and Methods; This study was conducted retrospectively between the years 2012-2017 among patients applying for Emergency Service at the University of Namiyaman School of Medicine. Acute initial neurological symptoms, including headache, encephalopathy, stroke, vision disorder or focal neurological defect, and five PRES phenomena identified in focal vasogenic swelling in brain imaging were taken to study. Facts were classified according to age, gender, emergency service application complaint,chronic disease, pregnancy status, BBT,MR and electroencephalographic (EEG) findings. As a result, the pres should be considered in women and pregnancies who apply for emergency service with headaches, loss of vision, loss of consciousness and especially convulsion. Keywords: PRES, emergency service, convulsion ABSTRACT Background: Posterior reversible encephalopathy syndrome (PRES) is a reversible syndrome accompanied by neurological and radiological findings by Hynchy J et al. in 1996. This syndrome is often referred with hypertension, headache, confusion, convulsions, vomiting, and loss of vision. The first being cerebral hyperperfusion due to suddenly elevated blood pressure and the associated vasogenic edema and the second endothelial dysfunction caused by endogenic and exogenous toxins. It is clinically characterized by various neurological findings that may develop acutely or subacutely. It can last for several hours or days and weeks. Material and method: This study was retrospectively performed between 2012-2017. Acute onset neurological symptoms including headache, encephalopathy, seizure, visual impairment or focal neurological deficit, and five PRES cases with focal vasogenic edema on brain imaging were included in the study. The cases were classified according to age, gender, complaint of emergency service, chronic disease, pregnancy status, BBT, MR and electroencephalographic (EEG) findings. Conclusion: As a result; emergency headaches, visual loss, loss of consciousness, and PRES in women and pregnant women, especially those who are referred for convulsions. Keywords: pres, emergency, convulsions
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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