Abstract:

Introduction: Researches done on the use of statins during the last two decades have shown conflicting results in their effects on DM, Cardiac, liver and Kidney functions. Six forms of statins are being prescribed as a preventive measure to reduce the incidence of cardiovascular morbidity and mortality; but statin use have also shown alternations in DM, liver and Kidney function. The latest observations relates to cancer prevention/induction. Statins prescriptions are done mostly for elderly patients in order to reduce lipid profile mostly Total cholesterol and LDL levels. Studies have shown that statins use affects muscular function, induce prediabetes, and alter liver enzymes and affects mitochondrial functions. Among the statins used, atorvastatin was found to be very beneficial with minimal side effects with greater beneficial function in maintaining other organ functions. Materials and methods: Total 50 patients were taken for this prospective, observational, cross-sectional hospital based study, conducted at Both rural and urban catchment area of N.R.S Medical College and Hospital, West Bengal from January 2016 to June 2017. The case records were studied, analysed and compared using SPSS (20.0) Results: The study reveals out of total 50 patients, 34 (68%) were male and 16 (32%) patients were female in the age group of 35 to 75 years. There were no abnormal changes (rise) in SGOT and SGPT level in 3 months. At the end of 6 months, overall increase of SGPT was seen in 3 patients (6%) of which out of 20 patients who had taken Rosuvastatin, 1 patient (5%) had SGPT (129mg/dl) and in Atorvastatin cases 2 patients (6.7%) had SGPT(134mg/dl) and 143mg/dl.). After 6 months of study in both Rosuvastatin and Atorvastatin abnormal values of CPK were seen. Conclusions: Both the statins had a good safety profile with few adverse effects. This study showed that the Rosuvastatin is more cost effective compared to Atorvastatin. For future research the study should be done in a large sample and for long duration of period as a multicentre study.

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