Özet:

Aim. The study of features of sensibilization to spring trees in patients of Lviv region and analysis of the effectiveness of allergoimmunotherapy by the extract of spring trees (Diater Laboratorios, Іспанія). Materials and methods of research. There were examined 286 patients with clinical symptoms of pollen allergy. Skin prick-tests (SPT) were realized by the extraction “Trees mixture” by Diater Laboratorios, Spain. The level of specific IgE to the components of allergens was determined ImmunoCAP method («Phadia AB», Sweden). Allergoimmune therapy (SLIT) was carried out by the vaccine - "Spring Trees" mixture (Alnus glutinosa = 25,00%; Corylus avellana = 25,00%; Betula verrucosa = 25,00%; Fraxinus excelsior = 25,00%). Results of research. 98,3% of patients had positive SPT to the extract “Herbs mixture”. Among them: 68,1% -sensibilized only by allergens of pollen of  Fagale trees; 2,8% - only by Oleaceae family allergens; 23,9% - polyvalent sensibilization by spring trees. ImmunoCAP research – true sensibilization by allergen of Betulacea pollen was 77%. After the first step of SLIT the improvement of the state was in 83,1%; after the second step – in 94,1% of patients. Conclusion: The sensibilization profile of patients from Lvyv region included allergens of Betulacea and Oleaceae trees pollen. The revealed high level of sensibilization by ash allergens allows to recommend SPT for ash for the routine practice. SLIT by the combined vaccine “Spring trees” (Diater, Spain) demonstrated safety and high effectiveness Author Biographies Svitlana Zubchenko, Danylo Halytskyy Lviv National Medical University Pekarska str., 69, Lviv, Ukraine, 79010 PhD, Assistant Department of Clinical Immunology and Allergology

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