Özet:

Our study aims to reduce the damage caused by Paklitakselin (PAC) on the testicular organ, which has a chemotherapeutic effect, with the resveratrol (RES) protective effect. In the study, Wistar albino species male rats were divided into 4 groups in order to have 10 animals in each group, such as paklitaksel (PAC) (10mg/kg), resveratrol (RES) (10mg/kg) and paklitaksel+resveratrol (PAC+RES) (10mg/kg -10mg/kg). The TUNEL method was used to evaluate the overall structure of the tissues Hematoxylene-Eosine and apoptosis. Biochemically, the values of malondialdehyde (MDA), catalase (CAT) and superoxid dismutaz (SOD) in testicular tissue were seen in tissue samples. As a result, when tissues were histopathologically evaluated, unlike other groups, an increase in epithelial irregularities and the number of necrotic tubes in the PAC group, the expansion in the connective tissue areas was observed. According to the results of the TUNEL method, the number of TUNEL positive cells in the PAC group increased compared to the RES and PAC+RES groups. These findings showed that the oxidative stress created by PAC in the testicular tissue can be reduced by the antioxidant effect created by the name RES. When compared the MDA, CAT and SOD values in the testicular tissue, there was no meaning difference between the groups(p>0,005). After all, PAC causes very serious damage to the testicular tissue as it affects many organs. To prevent this damage, the use of RES during the use of PAC can also be protective and corrective in the testicles.

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