Abstract:

Antioxidants are important for the treatment of various diseases, including cancer that causes human death. This study was conducted to determine the antioxidant activities of Passiflora edulis Sims. and Passiflora ligularis Juss. fruit methanol extracts (DPPH, ABTS, β-carotene, FRAP and CUPRAC), total secondary metabolite amount (Phenolic, Flavonoid, Tannin), as well as to determine the anticancer potential against human colorectal cancer (HT-29) and human lung cancer (A549). Results indicated that the P. ligularis fruit methanol extracts exhibit high biological activity in all antioxidant activity experiments (DPPH, 59.30±1.28%, ABTS, 57.60±0.55%, β-carotene, 88.17±1.86%, FRAP, 1.07±0, 6 mg TE/g, CUPRAC, 9.01±0.38 mg TE/g). There is a good correlation between antioxidant activity and total phenolic. At 8 mg/mL, the extract of P. ligularis showed higher cytotoxicity against A549 cells than P. edulis extract. At 2 mg/mL and lower concentrations, the viability of HT-29 cells treated with both extracts was above 50%. In conclusion, P. ligularis and P. edulis are potential sources for future studies in the pharmaceutical industry.

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