Abstract:

Malignant mesothelioma is a neoplasm that originates from the serosal membrane of pleura, peritoneum, pericardium, and tunica vaginalis. It has been associated with exposure to asbestos. Malignant peritoneal mesothelioma (MPM) is the second most commonly encountered type of mesothelioma after pleura. In our study, we aimed to analyze the demographic characteristics and treatment options of the patients diagnosed with MPM. In our study, the average age of 16 patients (12 men and four women) was 66 (46-93) years. Fifteen patients had epithelioid, and one patient had biphasic histopathology. Hyperthermic intraperitoneal chemotherapy (HIPEC) was performed in 2 patients. There were 16 patients receiving first-line chemotherapy, 13 patients receiving second-line chemotherapy, four patients receiving third-line chemotherapy, and one patient receiving fourth-line chemotherapy. The median progression-free survival of patients receiving first-line chemotherapy was found 14.4 months (CI 95% 7.4: 21.4). The median overall survival of the patients was detected 22 months (CI 95% 16: 27.9%). In order to determine which group of patients will benefit from cytoreduction surgery+HIPEC or which group of patients should start with systemic chemotherapy or immunotherapy, there is a need for prospective, multidisciplinary studies and a more significant number of patients.

Keywords:

Abstract:

Malignant mesothelioma is a neoplasm that originates from the serosal membrane of pleura, peritoneum, pericardium, and tunica vaginalis. It has been particularly associated with exposure to asbestos. Malignant peritoneal mesothelioma (MPM) is the second most commonly encountered type of mesothelioma after pleura. In our study, we aimed to analyze the demographic characteristics and treatment options of the patients diagnosed with MPM. In our study, the median age of 16 patients (12 men and four women) was 66 (46-93) years. Fifteen patients had epithelioid, and one patient had biphasic histopathology. Hyperthermic intraperitoneal chemotherapy (HIPEC) was performed in 2 patients. There were 16 patients receiving first-line chemotherapy, 13 patients receiving second-line chemotherapy, four patients receiving third-line chemotherapy, and one patient receiving fourth-line chemotherapy. The median progression-free survival of patients receiving first-line chemotherapy was found 14.4 months (CI 95% 7.4: 21.4). The median overall survival of the patients was detected 22. months (CI 95% 16: 27.9%). In order to determine which group of patients will benefit from cytoreduction surgery+HIPEC or which group of patients should start with systemic chemotherapy or immunotherapy, there is a need for prospective, multidisciplinary studies and a more significant number of patients.