Abstract:

Purpose: Psödoxfoliation (PEX) is a clinically diagnosed, lens front capsule and/or pupil edge gray-white fibrogranular psödoxfoliation material in the front segment examination of the substance. Glocoma is a chronic optical neuropathy, which is often seen with an increase in eye pressure, which causes optical nerve degeneration; retina ganglion cell degeneration and vision area loss. In this study we aimed to investigate whether this single nucleotid polymorphism (SNP) found in the CLU gene in the Turkish population is associated with PEX. Method: In the case group included 100 PEXG patients who had no relative relationship with each other. In the control group, there were 100 healthy volunteers who had no relative relationship. The genotyping of the SNP (rs11136000) in the CLU gene was made using the method of polymerase chain reaction (PZR) and restriction fragment length polymorphism (RFLP). Results: A series of variants (rs11136000) in the CLU gene have been identified in relation to PEX in different populations. In the patient group C, the frequency of allel was higher. In the control group, the T-allel frequency was too high. Accordingly, the likelihood of developing the disease is higher in people with C alley, while in people with T alley is less. Result: The results of the evaluations have found that there is no statistically meaningful relationship between CLU gen rs11136000 T>C polymorphism and PEX disease. Keywords: Psychoexfoliation Syndrome, CLU Geni, rs11136000, Polymorphism