Abstract:

The new coronavirus disease 2019 (COVID-19) pandemic continues to exist as an unavoidable crisis that affects the whole world. The old drugs with anti-inflammatory activity have come to the fore again in the search for treatment to reduce the morbidity and mortality of the disease. Colchicine is an alternative drug with immunomodulatory and potential anti-viral properties. Control of hyper inflammation triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most important stage for the development of acute respiratory disease syndrome (ARDS). Because of inhibiting different inflammation pathways, colchicine treatment may be effective in preventing the development of ARDS associated with mortality in COVID-19. Again, the lack of immunosuppression effect, ease of use, and being economical are its superior features compared to other drugs. In this review, along with colchicine treatment, non-steroidal anti-inflammatory drug (NSAID) applications used in COVID-19 mostly due to its acute anti-inflammatory effects will be discussed in the light of current information.

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