Özet:

Purpose: Solomon Demirel University School of Medicine (SDUTF) is intended to investigate the relationship between the anti-citrus peptide (anti-CCP) antibodies and the levels of IL-6 with clinical activity in patients with rheumatoid arthritis (RA) referring to the Romatology Clinic. The majority of patients with ankylosan spondylitis (AS) (E/K; 4/25) who meet the criteria of clinically active 30 RA patients (E/K; 3/27) and 22 healthy controls (E/K; 2/20) and the criteria of the European Spondylarthropy Working Group (ESSG) (E/K; 4/25) who meet the criteria of the American Romatology Association (ACR) criteria followed by the SDUTF Romatology Unit. Our study also used the Bath Ankylosan Spondylitis Disease Activity Index (BASDAI) for patients with IL-6, ESR, CRP and RA as a indicator of clinical activity. Results: There was no meaningful correlation between anti-CCP antibody positive and DAS 28 score (r = 0.172, p = 0.364) when all RA events were assessed. There is a very meaningful relationship between the DAS 28 score and the CRP (r = 0.525, p = 0.006) while there is no meaningful relationship between the IL-6 values (r = 0.09, p = 0.629). Although there were medium-positive correlations between the anti-CCP antibodies and CRP (r = 0.399, p = 0.029) and between the anti-CCP and ESH (r = 0.490, p = 0.006) in the group of patients with RA, it was not with IL-6 (r = 0.146, p = 0.440). However, a significant correlation was found when compared the levels of IL-6 with anti-CCP antibodies titres (r = 0.462, p = 0.01). There is no connection between anti-CCP antibodies and IL-6 levels and clinical activation in patients with RA. However, a positive correlation between anti-CCP antibodies and IL-6 levels has been found, and we consider that it requires more comprehensive studies to investigate the clinical importance.

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