Özet:

Purpose: Metoclopramide (MCP) is a drug that is widely used in the clinic in the presence of nausea, vomiting (symptom/symptom) and in recent years during the lactation period. There is no molecular study in literature on the side effects that the use of MCP during breastfeeding may cause in the newborn. Our study aims to study the proliferative changes that MCP can cause in the newborn liver tissue. In the study, 18 female Wistar-albino were divided into 3 groups with newborn rats and cats. Healthy control, low dose MCP applied group, high dose MCP applied group. The experiment continued throughout the lactation period and at the end of 21 days, the levels of 5-Bromo-2-Deoxyuridin (BrdU), Ki-67 and proliferate cell nuclear antigen (PCNA) with immunohistochemic painting in the liver tissue of pets were assessed; the levels of ELISA and BrdU and Ki-67 in tissue homogenity were assessed. Results: The control group found that the BrdU, PCNA and Ki-67 immune reactions in the hepatosites around the central vein were moderate, while the low and high doses of metoclopramides were statistically significantly increased according to control. Tissue homogenates at BrdU and Ki-67 levels were statistically significantly increased according to control in both low and high doses MCP groups. In both low and high doses of MCP groups, the increase in the BrdU, PCNA and Ki-67 immune reaction shows that this agent affects the DNA synthesis in the cell. This can also cause an excessive proliferation index.

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