Özet:

Purpose:Urinary system infections (USE) are the one that is common among bacterial infections and the isolated factor of these infections is Escherichia coli (E.coli).In this study, we aimed to identify the appropriate empirical treatment options for our region by evaluating the antibiotic resistance of E.coli in the urine culture.Materials and Methods: In this study, from April 2016 to December 2017, 21488 urinary cultures from various clinics and services were examined retrospectively.For the identification of bacteria isolated from the urine cultures and antibiotic sensitivity tests, the Phoenix (Becton Dickinson Diagnostics, USA) automated system was used.™A total of 2265 E.coli drugs were isolated from 1875 clinics and 390 service patients. The findings are: 99.2 percent amicase, 98.4 percent imipenase, 97.6 percent nitrofuranto, 97.3 percent meropenase, 96.8 percent phosphoma and 84.4 percent gentamis; 99.1 percent amicase, 96.6 percent imipenase, 96.5 percent phosphoma, 95.7 percent nitrofuranto, 93.1 percent meropenase and 82.2 percent gentamis. Result: Monitoring the regional antibiotic resistance rates is necessary in order to give direction to empirical treatment. Thus, both the patient’s treatment will be effectively carried out and the loss of time and cost caused by inappropriate empirical treatment will be prevented. According to the results we found in our study, amikasine, gentamisine, imipenem, meropenem, nitrofurantoin and phosphomy should be preferred first in the ampyric treatment of urinary system infections in our region.

Anahtar Kelimeler:

Özet:

Objective: Urinary tract infections (UTI) are the most common bacterial infections and Escherichia coli (E.coli) is the most isolated pathogen from UTI. In this study we aimed to evaluate antibiotic susceptibility profiles of E.coli strains isolated from urine cultures and to determine appropriate alternatives of empirical treatment in our region. Materials and Methods: In this study 21448 urine cultures of the patients who admitted to various departments between April 2016 and December 2017 were evaluated retrospectively. Automated system Phoenix™ (Becton Dickinson Diagnostics, USA) was used for identification and antibiotic susceptibility testing of bacteria obtained from urine cultures. Results: A total of 2265 E.coli strains were identified belonging to 1875 outpatients and 390inpatients. Antibiotic sensitivity rates were detected for E. coli isolated from outpatients as 99.2% to amikacin, 98.4% to imipenem, 97.6% to nitrofurantoin, 97.3% to meropenem, 96.8% to fosfomycin and 84.4% to gentamicin; from inpatients as 99.1% to amikacin, 96.6% to imipenem, 96.5% to fosfomycin, 95.7% to nitrofurantoin, 93.1% to meropenem and 82.2% to gentamicin. Conclusion: Regional antibiotic resistance monitoring is essential in order to guide empirical therapy. Thus, thetreatment of the patients will be done effectively and the loss of time and cost resulting from inappropriate empirical treatment will be prevented. In our study, we found that amikacin, gentamicin, imipenem, meropenem, nitrofurantoin and fosfomycin should be preferred for empirical treatment of urinary tract infections in our region.