Abstract:

OBJECTIVE: In our study, it was aimed to compare the systemic immune-inflammation index (SII), one of the inflammation parameters, between pregnant women diagnosed with ectopic pregnancy and healthy pregnant women. MATERIAL AND METHODS: This retrospective case-control study was conducted at a tertiary education and research hospital between July 2021 and October 2022. A total of 161 patients, which 55 pregnant women with tubal ectopic pregnancies and 106 healthy pregnant women were included. Demographic information and laboratory parameters of the patients were recorded. The patients were divided into two groups as tubal ectopic pregnancy and control group and compared in terms of SII, monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) inflammation markers. The SII value was calculated as: platelet count x (neutrophil/lymphocyte). RESULTS: No significant difference was found in the ectopic pregnancy group in terms of SII, NLR, PLR and MLR when compared with healthy pregnant women (p=0.308, p=0.216, p=0.124 and p=0.071). When the tubal ectopic pregnancy group was examined, there was no significant change in SII, NLR and PLR in ruptured ectopic pregnancies compared to non-ruptured tubal ectopic pregnancies (p=0.706, 0.354, 0.071) and a decrease in MLR levels was found (p=0.018). CONCLUSIONS: Although the inflammatory process in ectopic pregnancy is still being discussed with a limited number of studies in the literature, as a result of our study, we revealed that SII, NLR, PLR levels did not change in tubal ectopic pregnancy compared to healthy pregnancies, while MLR levels decreased in ruptured ectopic pregnancies.

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