Abstract:

Introduction: Diabetes mellitus is a metabolic disorder which is characterized by hyperglycaemia and insufficiency of the secretion or the action of endogenous insulin. Although the aetiology of the disease has not been well defined, viral infections, autoimmune diseases, and environmental factors have been implicated. With this background, the present study was undertaken to find the correlation of the serum uric acid and the glycemic control in patients with type 2 Diabetes mellitus. The proxy indicator used for glycemic control here was glycated hemoglobin level (HbA1C). Methodology: The present case control study was undertaken in the Department of Physiology of J.N.K.T. Medical College, Madhepura, Bihar, India. The study period was 6 months that was from May 2020 to October 2020. Prior ethical approval was obtained from the Institutional ethics committee. The subjects who were included in this study were divided into 2 groups: Group A included 20 normal healthy individuals, in the age group 40-65 years, of either sex and without any family history of DM. Group B included 20 diagnosed patients of Type 2 Non-Insulin Dependent Diabetes mellitus (NIDDM), who were in the age group 40-65 years, of either sex, from the same population. Results: The mean age of the patients in group A was 31.8 ± 7.9 years and that of patients in group B was 33.6 ± 6.8 years. In the control group, there was a slight male predominance with 55% being male, while in the study group, female dominant with 75%. There was no statistical difference between both the groups based on gender and age. The mean FBS level of group A was 76.2 ± 8.3 mg/dl and that of group B was 144.9 ± 62.4 mg/dl, which was significantly higher than that of group A (p < 0.05). Conclusion: In conclusion, our study suggests that there is an increase in the serum uric acid levels with an increase in the HbA1C levels. This showed a positive relationship in Type 2 Diabetes mellitus.

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