Abstract:

Purpose: In this study, we aimed at exploring the effects of local and systemic application of boric acid (BA) on the osseointegration of titanium implants in the rats. Tools and Methods: Titanium implants were surgically integrated into the right tibia bone of a sample group of 32 rats. The rats were divided into four treatment groups: controls (CNT) (n=8), local BA (LBA) (n=8), systemic BA (SBA) (n=8) and systemic and local BA (SLBA) (n=8). The controls did not see any application after implant surgery. Local BA was applied to implant sockets in the LBA group, then the implants were placed in the sockets. The SBA group was administered in periton 8 mg/kg. In the SLBA group, the local BA was applied to the implant sockets, then the implants were placed in the sockets; then the daily 8 mg/kg of BA was applied in periton. The trial period lasted 28 days, after which it was applied to animals and the implants were taken together with the surrounding bone tissue. Results: The rate of bone-implant coating (CIC) (%) was studied using non-decalsified histological method. In the SLBA and SBA groups, the KIC rates were higher compared to the controls and LBA groups (p<0.05) (p=0.004 p=0.002 p=0.011 p=0.013). Although the KIC ratio in the SLBA group is at a numeric level compared to the SBA group, it does not make a difference in the statistical level (p>0.05 p=0.38). Result: Within the limits of this study, it can be concluded that by local application, the systematic and only systematic BA application can increase the osseointegration of titanium implants.

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