Özet:

The effect of antiepileptic drugs on serum lipid concentrations is well known. We investigate the effect of VPA usage on lipid profile. Serum lipid profiles of 25 epileptic patients followed with the VPA mono treatment and a control group consisting of 25 cases with similar sex ratio and ages were measured. The age and sex ratio of the cases in VPA using group and control group were not significantly different. According to control group it is detected that VPA usage has no effects on lipid profile. In the group of patients on VPA treatment, TK, HDL-C, LDL-C, VLDL-C, TG, TK/HDL and LDL/HDL levels were not affected from age, gender, serum level of VPA and the dose and duration of VPA treatment. Conclusion: Because different results were reported in several reports about the effect of VPA on serum lipid profile, which must be used in long term period for the treatment of epilepsy, no consensus has been made. So that we agreed that serum lipid profile must be regularly measured in patients using VPA

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