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Objectives: Even though magnetic resonance imaging has been described as the most effective imaging method for the diagnosis of liver fibrosis, an accepted magnetic resonance ımaging (MRI) technique is yet to be defined. The aim of this study is to determine the efficiency of MRI in the staging of liver fibrosis. Methods: Patients with chronic hepatitis B infection and had upper abdominal MRI with hepatocyte specific contrast agent were evaluated. Twenty-nine patients that had undergone liver biopsy were included in the study. ADC, FA, and signal intensity values of liver parenchyma were measured by two observers and contrast enhancement index (CEI) was calculated as well. Patients were grouped as early (A) and late fibrosis(B) according to Ishak grading system and then the correlations between the stage and MRI findings were analysed. The intraclass correlation coefficient was used to analyze the inter-rater agreements. ADC, FA, and CEI were compared with Student t-test between early and late fibrosis groups. Pearson’s correlation was used to assess the correlation between ADC and FA values. Spearman correlation was used to evaluate the relationship between pathologic fibrosis grade and MRI parameters that were measured. Results: Twenty-two patients were staged as 1 and 2 (group A), seven patients were staged as 3 and above fibrosis(group B). Statistically, there was a strong, negative correlation between the FA values and the degree of fibrosis (r=−0.582, p=0.001). There was no correlation between the CEI and hepatocyte activity index (r=−0.88, p=0.655) and degree of fibrosis (r=0.0001, p=0.997). In terms of FA values, there was a statistically significant difference between two groups (group A=0.429 ± 0.06, group B=0.349 ± 0.06) (p=0.004). Conclusion: Correlation of FA values with fibrosis stage and significant difference in FA values between early-late stage fibrosis patients shows that diffusion tensor imaging can be a promising technique in the staging and follow-up of liver fibrosis.
Purpose: Although magnetic resonance imaging (MRG) is defined as the most effective method of imaging in the diagnosis of liver fibrosis, a accepted MR technique for this is not yet defined. The aim of this study is to determine the effectiveness of MRG in the phase of liver fibrosis. Method and means: Patients with the upper-west MRG taken with the specific contrast substance of hepatosite in the hospital database were selected among the patients followed by the cause of chronic hepatitis B infection. Among them, 29 patients with a hepatic biopsy were included in the study. The visible diffusion rate (ADC), the fractional anizotropy (FA) and the signal intensity values were measured by two observers and the contrast index was calculated. Patients were grouped as early (A) and late stage fibrosis (B) according to the histopathological Ishak rating system and then the correlation between the fibrosis stage and the MR parameters was analyzed. The intraklas correlation ratio was used to analyze the inter-observator compatibility. The ADC, FA and contrast index were compared with the Student-t test between early and late fibrosis groups. To evaluate the correlation between the ADC and FA values, Pearson used Spearman correlation to evaluate the relationship between the pathological fibrosis stage and the MR parameters measured. Results: 22 patients were classified as phase 1 and 2 (Group A), 7 patients were classified as phase 3 and above fibrosis (Group B). Statistically, there was a strong, negative correlation between FA values and fibrosis degree (r = -0.582, p = 0.001). There was no correlation between the contrast index and the hepatosite activity index (r = -0.88, p = 0.655) and the degree of fibrosis (r = 0.0001, p = 0.997). In terms of FA values, there was a statistically significant difference between early and late phase fibrosis groups (group A = 0.429 ± 0.06, group B = 0.349 ± 0.06)(p = 0.004). Results: The correlation of FA values with the phase of fibrosis and the significant difference in terms of FA values between early and late phase fibrosis patients; diffusion tensor imaging indicates that it can be a hopeful technique in the development and tracking of liver fibrosis. (SETB-2021-08-246)
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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