Özet:

Atrial fibrillation is the most frequent arrhythmia after open heart surgery. The aim of this study was to determine the effect of intravenous (IV) N-acetyl cys-teine (NAC) administration in the early postoperative period of coronary ar-tery bypass (CABG) surgery on the incidence of postoperative atrial fibrillation (POAF). A total of 60 patients who had undergone isolated CABG surgery be-tween June 2014 – July 2015 in our clinic included in this retrospective study. The patients divided into two groups: Group 1 (n=30) included the patients who had been administered standard saline solution infusion and Group 2 (n=30) included the patients who had been administered IV NAC (10mg/kg) infusion while they were under mechanical ventilation support. All patients were ad-ministrated oral 600 mg NAC once a day for 5 days after weaning from me-chanical ventilation support. The ECG’s were evaluated for POAF by the same cardiovascular surgeon who was blinded for patient groups. POAF was seen in 12 (40%) patients in Group 1 and 4 (13%) patients in Group 2. The POAF incidence was significantly higher in Group 1 (p=0.020). We think that admin-istration IV NAC is an effective way to prevent the POAF after CABG surgery.

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