Abstract:

In this research, in vitro antibacterial activities of ten mono, -di and -trisubstituted-2-phenylbenzimidazoles against six species (Klebsiella pneumoniae, Echerichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, Streptococcus fecalis) were investigated. The synthesis, structure elucidations and in vitro antituberculosis activity results of these compounds were given in our previous study(l). In investigation of in vitro antibacterial activity of the compounds, the serial Dilution Method in Test Tubes was employed. The in vitro antibacterial activity results of the compounds were compared to erythromycin's and chloramphericol's and the activities of the compounds 1,6,7 and 10 against S. aureus (MIC: 12,5 g/ml) and compound 8 against K. pneumoniae (MIC: 12,5 g/ml), were found noteworthy. In addition to these, compound 7 was observed more active against B. subtilis (MIC: 3,1 g/ml) among these compounds.

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