Abstract:

Purpose: The thyroid nodes are commonly seen. In the formation of these nodes, genetic and environmental factors as well as chronic inflammation also play a role. The key point in the diagnostic assessment is the exclusion of malignity. Biobelirects that may show malignity are continuing to be investigated. In our study, we evaluated the relationship between the erythrosite sedimentation rate, leukocytes, fibrinogens, C reactive proteins and inflammatory biobeliracts with thyroid nodules characteristics and cytologies. Methods: This study formed a nodular guatr group of 55 patients and a control group of 58 healthy individuals. The participants’ gender, age, family history, thyroid function tests, sedimentation, leukocytes, fibrinogenic, CRP and pentraksin-3 serum levels were recorded. In the ultrasound, the number of nodes, the largest nodes diameter, the structures of the nodes were studied and thyroid biopsy was performed. Results: The number of thyroid nodes in patients was between 1 and 4. The number of patients with two thyroid nodes was greater (47,3%, n: 26). The nodular diameter varied between 3-62 (medium 21) mm. In the thyroid biopsy, 25.5% of patients (n: 14) were diagnosed with papillary thyroid cancer. As the CRP values increase, the number of nodes in the ultrasound increased (p=0.013). As fibrinogenic values increased, the number of nodes in the ultrasound also decreased (p=0,003). There was no significant difference between the groups in terms of sedimentation, leukocytes and pentraksin-3 values. The number of nodes showed a negative correlation with the positive, fibrinogenic levels with CRP. This clinical follow-up may be important. But there was no difference between the benign and malign distinction and the biobelirects. CRP values that correlate with the increase in the number of nodules can be used in prognosis and clinical tracking. (SETB-2021-03-063)

Keywords: