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2
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15
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3
Viral infections such as herpes viruses (CMV, EBV, HHV-6, HSV-1 and 2, VZV), adenovirus, and polyomavirus (BK virus) may lead to considerable morbidity and mortality in allogenic hematopoietic stem cell transplanted children (HSCT), mainly due to iatrogenic T cell dysfunction. To manage these infections, different strategies like matching of host and donor, viral surveillance, antiviral prophylaxis and preemptive antiviral treatment have been tried and combined, since these infections have become more recognised and can be monitored by quantitative real-time polymerase chain reaction. Viral infections associated with high morbidity and mortality in HSCT patients can be prevented by early diagnosis through the molecular diagnostic techniques and timely initiation of appropriate treatment options.
Viral infections such as herpes viruses (CMV, EBV, HHV-6, HSV-1 and 2, VZV), adenovirus, and polyomavirus (BK virus) may lead to considerable morbidity and mortality in allogenic hematopoietic stem cell transplanted children (HSCT), mainly due to iatrogenic T cell dysfunction. To manage these infections, different strategies like matching of host and donor, viral surveillance, antiviral prophylaxis and preemptive antiviral treatment have been tried and combined, since these infections have become more recognized and can be monitored by quantitative real-time polymerase chain reaction. Viral infections associated with high morbidity and mortality in HSCT patients can be prevented by early diagnosis through the molecular diagnostic techniques and timely initiation of appropriate treatment options.
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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