Abstract:

Recent studies suggest that dietary advanced glycation end products (AGEs) play an important role in both reproductive and metabolic dysfunctions associated with polycystic ovary syndrome. Advanced glycation end products are reactive molecules formed by the non-enzymatic glycation process between reducing sugars and proteins, lipids or nucleic acids. Advanced glycation end products may contribute to the pathogenesis of polycystic ovary syndrome by activating key intracellular signaling pathways, stimulating the formation of oxidative stress and proinflammatory cytokines. While advanced glycation end products can occur endogenously under normal metabolic conditions, they can also be taken into the body exogenously, especially when consuming foods cooked and processed at high temperatures such as frying, baking or grilling. It has been reported that women with polycystic ovary syndrome have increased serum levels of AGEs, which cause anovulation and hyperandrogenism in ovarian tissue. This review aims to present the role of advanced glycation end products as mediators of metabolic and reproductive changes in polycystic ovary syndrome.

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