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Asimetrik dimetilarjinin (ADMA) ve nitrik oksit (NO), etki mekanizmalarını karşılıklı olarak gösterirler, bu moleküller arasındaki denge hava yolu tonusunun ve fonksiyonunun sıkı düzenlenmesine katkıda bulunur. Çalışmamız kronik obstrüktif akciğer hastalığı (KOAH), tedavisinin kandaki hemogram, total IgE ve serum ADMA, NO düzeylerine ve solunum fonksiyon testi (SFT) değişimlerine olan etkisine bakmayı amaçlamıştır. Çalışmada seçilen tedavi öncesi ve tedavi sonrası gruplarından alınan kan örneklerinden total IgE, hemogram ve serum ADMA, NO düzeylerine bakıldı. Serum ADMA ve NO düzeyleri ise NO ticari ölçüm kiti kullanılarak ELISA yöntemiyle, hemogram ve total IgE değerlerine ise otomatik kan sayım cihazında bakılmıştır. Kontrol ile tedavi öncesi serum ADMA düzeyleri arasında anlamlı fark bulunurken (p<0.05) tedavi sonrasındaki grupla arasında anlamlı fark bulunmadı (p<0.05). KOAH’lı bireylerde yapılan tedavi kontrol grubu düzeyi ile olan ADMA farkını azaltmıştır. Tedavi öncesi ile tedavi sonrası ADMA düzeyleri arasındaki fark anlamlı bulunmamıştır (p<0.05). Kontrol ile tedavi öncesi ve tedavi sonrası grupların NO konsantrasyonları arasındaki fark anlamlı bulunurken (p<0.001), tedavi öncesi ile tedavi sonrası NO düzeyleri arasındaki fark anlamlı bulunmamıştır (p<0.05). Kontrol ile tedavi öncesi ve tedavi sonrası grupların total IgE konsantrasyonları arasındaki fark istatistiksel olarak anlamlı bulunmuştur (p<0.001). Tedavi öncesi ile tedavi sonrası grupların total IgE düzeyleri arasındaki fark anlamlı bulunmamıştır (p<0.05). Tedavi öncesi ve tedavi sonrası grupların KOAH serum ADMA ile NO değerleri arasında önemli negatif bir ilişki bulunmuştr. KOAH’lı bireylerde ADMA düzeylerinin yüksek, NO düzeylerinin düşük olduğunu ve her ikisinin de hava akımı sınırlaması derecesi ile güçlü bir korelasyon gösterdiğini gözlemledik. ADMA, KOAH prognozunun olası yeni bir göstergesi gibi görünmektedir ve KOAH tedavisinde yeni bir potansiyel tedavi hedefi olabilir.
The mechanisms of asymmetric dimetylary (ADMA) and nitric oxide (NO) are mutual, contributing to the strict regulation of the tone and function of the airway between these molecules. Our study aims to look at the effect of chronic obstructive lungs disease (KOAH), the hemogram of treatment in the blood, total IgE and serum ADMA, NO levels and changes in respiratory function test (SFT). The study looked at the total IgE, hemogram and serum ADMA, NO levels from blood samples taken from the selected pre- and post-treatment groups. Serum ADMA and NO levels are considered using the ELISA method using the NO commercial measurement kit, while the hemogram and total IgE values are considered in the automatic blood counting device. There was no significant difference between the control and pre-treatment serum ADMA levels (p<0.05) and the post-treatment group (p<0.05). The treatment in individuals with KOAH has reduced the ADMA difference with the level of control group. There was no significant difference between the levels of ADMA before and after treatment (p<0.05). The difference between control and NO concentrations in pre- and post-treatment groups was significant (p<0.001), while the difference between pre- and post-treatment NO levels was not significant (p<0.05). The difference between the total IgE concentrations of the control and pre-treatment and post-treatment groups was statistically significant (p<0.001). There was no significant difference between the total IgE levels of the pre-treatment and post-treatment groups (p<0.05). There has been a significant negative relationship between the ADMA serum and NO values of the pre- and post-treatment groups. In individuals with KOAH, we observed that ADMA levels were high, NO levels were low, and both showed a strong correlation with the degree of limitation of air flow. ADMA appears to be a possible new indicator of KOAH prognosis and may be a new potential treatment target in KOAH treatment.
Asymmetric Dimethyl Arginine (ADMA) and Nitric Oxide (NO) show reciprocal mechanisms of action and the balance between these molecules contributes to tight regulation of airway tone and function. Our study aimed to examine the effects of chronic obstructive pulmonary disease (COPD) therapy on serum ADMA, NO levels, pulmonary function tests (PFT) changes, hemogram and total IgE levels. Serum ADMA, NO, total IgE, hemogram levels of the blood samples taken from the study groups were examined. Serum ADMA and NO levels were determined by ELISA method using NO commercial measurement kit, hemogram and total IgE values were measured in automatic blood counter device. There was a significant difference between control and pre-treatment serum ADMA levels (p>0.05) but there was no significant difference between control and post-treatment serum ADMA levels (p>0.05). Treatment with COPD patients reduced the ADMA difference with the control group level. The difference between pre-treatment and post-treatment ADMA levels was not significant (p> 0.05). There was a significant difference (p>0.001) between control and pre-treatment and post-treatment groups NO concentrations, but the difference between pre-treatment and post-treatment NO levels was not significant (p> 0.05). A statistically significant difference was found between control and pre- and post-treatment total IgE concentrations (p>0.001). The difference between pre-treatment and post-treatment total IgE levels was not significant (p> 0.05). Pre- and post-treatment COPD had a significant negative correlation between serum ADMA and NO levels. In COPD patients we found that ADMA levels were high, NO levels were low, and both correlated strongly with airflow limitation level. ADMA appears to be a potential new indicator of COPD prognosis and may be a potential new therapeutic target in the treatment of COPD.
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