Abstract:

Bacteria are gaining resistance to antibiotics and their derivatives day by day, and this is becoming a global problem. It is thought that this global problem can be prevented due to the antioxidant and antimicrobial activities of the secondary metabolites (phenolic compounds, etc.) found in plants. In this context, various studies have been carried out. Resistance to antibiotics and their derivatives can be overcome by identifying components that act as antioxidants, antimicrobials, and anti-biofilms from plant sources. Alyssum filiforme is a member of the Brassicacea family, which is rich in B vitamins and magnesium. Alyssum filiforme is an endemic species with the potential to be evaluated in this context. In this study, the antimicrobial, anti-biofilm, antioxidant, and phenolic profile of the endemic Alyssum filiforme species was determined by RP-HPLC-PDA. Minimum Inhibition Concentration (MIC) and Minimum Bactericidal Concentration (MBC) methods were applied for the antimicrobial activity of the obtained extract, and 2,2-diphenyl-1-picrylhydrazil (DPPH) radical scavenging activity and iron reducing antioxidant power (FRAP) were used to determine the antioxidant activity. To observe the effectiveness in preventing biofilm formation, the crystal violet bonding method was used, and positive results were obtained in all bacteria. FRAP and DPPH results were determined as 13.070 μmol FeSO4.7H2O/g and SC50 5.190 mg/ml, respectively. As a result of the obtained phenolic analysis, it was found that the plant is rich in caffeic acid and chrysin. In the light of the results obtained, Alyssum filiforme is thought to be a valuable species in terms of health