Özet:

Aim: To investigate the effect of the addition of micronized purified flavonoid fraction (MPFF) on occurrence and severity of symptoms in patients who underwent rubber band ligation (RBL) for hemorrhoidal disease (HD). Method: Patients who underwent RBL for HD in a single clinic in 2020 were retrospectively assessed. Patients aged ≥ eighteen years treated by a single surgeon for stage II and III internal HD with RBL and MPFF or RBL alone were included. The patients were divided into those who received combined therapy (RBL+MPFF) and those who only had RBL. The presence of bleeding, pain, and/or itching and occurrence of prolapse were recorded at the time of admission and on visit 1 (seventh post-operative day) and visit 2 (28th post-operative day). Complications arising from RBL were also recorded. All patients were asked to evaluate general anal area comfort with a visual analog scale at admission and each visit. Results: The rate of bleeding on the first visit was significantly lower in the RBL+MPFF group compared to RBL alone (p<0.05). The proportion of patients with persistent pain and itching and prolapse tended to be lower in the RBL+MPFF group but the difference was not significant. Anal region comfort scores were significantly higher in the RBL+MPFF group at both visit 1 and 2 (p<0.05). The complication rate was lower in the RBL+MPFF group compared to the RBL only group, but this did not reach statistical significance (p>0.05). Conclusion: Giiving MPFF to patients undergoing RBL provides earlier control of bleeding, the most common symptom. Combined therapy results in an improvement in general anal area comfort compared to RBL alone.

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