Abstract:

Objective: Postoperative nausea-vomiting (PONV) is one of the most common side effects after anesthesia. PONV extends the duration of hospital stay and recovery time of the patient after the surgery. In this study, we compared the effects of tropisetron on palonosetron on postoperative nausea and vomiting after laparoscopic cholecystectomy. Methods: After endotracheal intubation, Palonosetron Group (Group P) received iv 0.075 mg of palonosetron and Tropisetron Group (Group T) received iv 5 mg of tropisetron. VAS scores, antiemetic use and nausea-vomiting scores were recorded in 0-72 hours interval. Results: In the 0-24 and 48-72 hour intervals, there were no statistical difference between the groups with regard to nausea-vomiting scores, but, in the 24-48 hour interval, nausea-vomiting score was lower in Group P than Group T (p < 0.024) (Table 3). There was no statistical difference in all 72 hour intervals with respect to antiemetic use (p > 0.05). 72 hours total antiemetic use was statistically higher in Group T than Group P (p = 0.025) (Table 4). Conclusion: For PONV prophylaxis, palonosetron decreased the PONV score and antiemetic need more than tropisetron in the first 72 hours.

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