Özet:

Purpose: In this study, we tried to determine the frequency of 25-hydroxyvitamin D (25(OH)D) deficiency in primary hyperparathyroid patients and to investigate whether meshical variation affects 25(OH)D levels. Methods: The study included 156 patients diagnosed with primary hyperparathyroidism and 80 controlled patients. Demographic and laboratory data were recorded Results: Parathormone (PTH) (p<0,001), Calcium (Ca) (p<0,001) and alkaline phosphate (ALP) (p<0,001) values of primary hyperparathyroid (PHP) patients were significantly high according to the control group, while 25(OH)D (p:0.011) and phosphorus (P<0,001) levels were significantly low. In PHP patients, 25(OH)D deficiency was detected at 75% while 25(OH)D deficiency was detected at 18%. The 25(OH)D deficiency in the control group was found at 70% of the rate. When we seasonally examined the level 25(OH)D of PHP patients, there was no statistically significant difference in the average level 25(OH)D (p:0.14). In PHP patients, with 25(OH)D deficiency, the level of PTH (p:0.007) was significantly high compared to 25(OH)D deficiency and sufficient group, while the level of P (p:0.03) was significantly low. Discussions: in PHP patients, the 25(OH)D deficiency is more common than in healthy populations, regardless of season and geography, and is associated with the severity and complication of the disease. The prevalence of 25(OH)D deficiency in primary hyperparathyroid patients was higher than in healthy populations. In primary hyperparathyroid patients, the level of 25(OH)D is low independently of the season.

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