Özet:

Aim: The aim of this study is to investigate types of both major chromosomal abnormalities and Y-chromosome microdeletions by examining with standard cytogenetic methods and Y-chromosome microdeletion analyzes for azoospermia and / or oligozoospermia etiology to provide appropriate genetic counseling to men admitted to our hospital due to infertility before assisted reproductive techniques. Material and Methods: A total of 437 patients who admitted to our Kanuni Sultan Süleyman Training and Research Hospital due to male infertility between 2017 and 2020 were included in our study. All patients were evaluated according to spermiogram, hormonal profile, chromosome analysis and Y microdeletion analysis. Results: In our study, chromosomal anomalies were detected in 42 of 437 patients (9.6%). The most common chromosomal anomaly was 47, XXY (Klinefelter syndrome). 5 of our patients had stable translocation. Marker chromosome was detected in 1 patient. Chromosome analysis of the remaining 395 patients was normal. Various y-chromosome microdeletions on AZF genes were detected in 44 patients (10.06%). AZFa in 1 patient, AZFb + c in 4 patients, AZFc gr / gr in 17 patients, complete AZFa + b + c in 2 patients, complete AZFc in 2 patients, partial AZFb in 1 patient, partial AZFb + c in 9 patients, and partial AZFc were detected in 8 patients. No Y chromosome microdeletions were detected in the remaining 393 patients. Conclusion: In the light of current information and past literature studies, we recommend chromosome analysis and y-micro deletion analysis, especially in patients with severe oligospermia and azoospermia, before assisted reproductive techniques.

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