Abstract:

Purpose: Excessive stretching and breakdown occurring in post-trauma alveols, separation of alveols from bronchiols, intraalveol bleeding, interstitial swelling and eventually occurring alveolocapils are expressed as liver contusion damage. In recent years, the number of studies on the effects of antioxidants on the experimental model of lungs containment is increasing. The purpose of this study is to investigate the effectiveness of carnosol and dexametazone in the traumatic lungs containment. Tools and Methods: In the study, a total of 50 Wistar Albino female rats were used in the weight range of 180-220 grams of 6-8 months. The rats were equally divided (n=10) into five main groups. Ratlarsham group was divided into 5 groups as carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group, carnosol group. After 48 hours, the rats were sacrificed under anesthesia. The right lung tissue was taken for both histopathological and biochemical examination. The blood sample taken during the sacrament was evaluated for biochemical examination. Results: Serum and tissue samples; total oxidate, total antioxidant and oxidative stress levels were studied by measuring and taking into account histopathological changes. In our study, the pathological study of carnosol and deksametazonated groups showed statistically meaningful improvements according to the control group in terms of interstitial swelling (p=0,048), interstitial hemorrhoea (p=0,014) and alveolar conjunction (p<0,01). In the biochemical study of the groups, the TOS is the highest in the trauma model, and although it is lower in the treatment groups, there is no statistically significant difference between all groups.        The result is that the carnosol and dexametazone that we use in liver containers may be positive in the prevention of the negative effects of the containers, especially in the context of histopathological assessments.

Keywords: