Özet:

Objective: Lumbar disc herniation (LDH) is a socio-economic burden. The physiopathology of the disease is not clarified completely. This study aimed to investigate the oxidation-reduction balance in LDH via serum thiol-disulfide and ischemia-modified albumin (IMA) levels. Materials and Methods: This prospective case-control study included 30 patients with LDH and a control group with 30 healthy volunteers. Blood samples were analyzed for total thiol (-SH+ -S-S-), native thiol (-SH), and IMA levels. Disulfide levels and native thiol/total thiol ratio were calculated. The results of the two groups were compared. Results: Native and total thiol levels were significantly higher in the LDH group than in the control group (p=0.007 and p=0.008, respectively). IMA levels were significantly higher in the LDH group than in the control group (p=0.000). The receiver operating characteristic curve demonstrated that the IMA value of 1.41 could predict the LDH with 80% sensitivity and 80% specificity (area under curve=0.888, confidence interval: 0.802-0.974). Conclusion: LDH influences the thiol-disulfide balance, and increased IMA levels can predict LDH.

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